AMPK activator (nucleoside analogue)
A nucleoside analogue and AMPK activator widely characterised in metabolic-research literature. Often co-studied with peptide metabolic compounds.
| Compound | AICAR |
| Research category | Metabolic Research |
| Available sizes | 50mg, 100mg |
| Pricing | From £40 |
| Format | Lyophilised powder in sealed vial |
| Purity | >99% by HPLC (Janoshik Analytical, batch-verified) |
| Intended use | In-vitro laboratory research only. Not for human consumption. |
Reference data drawn from public databases (PubChem, UniProt) and peer-reviewed literature. For research and laboratory characterisation only.
| Compound class | Small-molecule AMPK activator (5-aminoimidazole-4-carboxamide ribonucleotide) |
| Molecular formula | C9H14N4O5 |
| Molecular weight | 258.23 g/mol |
| CAS Registry Number | 2627-69-2 |
| PubChem CID | 17513 |
| Receptor / mechanism | AMPK pathway activator; AMP analogue. |
| Reported half-life | Reported short serum half-life in published preclinical literature. |
| Solubility | Lyophilised powder reconstitutes in bacteriostatic water for laboratory use. |
| Storage (lyophilised) | Stable at 2–8 °C lyophilised for 24+ months. |
| Storage (reconstituted) | Reconstituted: store at 2–8 °C, use within 14 days. |
| Clinical / regulatory status | Preclinical / investigational. |
AICAR (Acadesine, 5-aminoimidazole-4-carboxamide ribonucleotide) is a small-molecule analogue of AMP characterised in the literature as an activator of AMP-activated protein kinase (AMPK) in cellular models. Supplied for in-vitro research use only.
The above describes how this compound is characterised in the published peer-reviewed literature. It is not a claim about effects in humans.
AICAR is supplied as a lyophilised (freeze-dried) powder in a sealed glass vial. For laboratory reconstitution, add the desired volume of diluent (typically bacteriostatic water) slowly down the side wall of the vial. Swirl gently until fully dissolved - do not vortex or shake. Store reconstituted solutions at 2–8 °C and use within 4–6 weeks.
Use our Reconstitution Volume Calculator to compute the resulting mg/ml concentration.
| State | Temperature | Shelf life |
|---|---|---|
| Lyophilised | 2–8 °C or −20 °C | Up to 24 months |
| Reconstituted | 2–8 °C | 4–6 weeks typical |
Every batch of AICAR we supply is independently HPLC-verified by Janoshik Analytical. Where a Janoshik report has been issued for the current batch it is supplied with the order and carries a unique verification key that can be authenticated against Janoshik's records. Reported purity is consistently above 99%.
Researchers working with AICAR often work alongside the following compounds in the preclinical literature: