Modified IGF-1 analogue
A modified IGF-1 analogue with reduced binding to IGF binding proteins, giving an extended half-life relative to native IGF-1.
| Compound | IGF-1 LR3 |
| Research category | GHRH / Secretagogue Research |
| Available sizes | 0.1mg, 1mg |
| Pricing | From £25 |
| Format | Lyophilised powder in sealed vial |
| Purity | >99% by HPLC (Janoshik Analytical, batch-verified) |
| Intended use | In-vitro laboratory research only. Not for human consumption. |
Reference data drawn from public databases (PubChem, UniProt) and peer-reviewed literature. For research and laboratory characterisation only.
| Compound class | Long Arg-3 IGF-1 - recombinant analogue with extended N-terminus |
| Molecular formula | Recombinant analogue |
| Molecular weight | 9,117 Da |
| CAS Registry Number | 946870-92-4 |
| Number of residues | 83 |
| Amino acid sequence | 83-amino-acid analogue: 13-residue extension at N-terminus + Arg³ substitution of native IGF-1. |
| Receptor / mechanism | IGF-1 receptor agonist with reduced IGFBP binding. |
| Reported half-life | Reported ~20–30 hours in human serum. |
| Solubility | Lyophilised powder reconstitutes in bacteriostatic water for laboratory use. |
| Storage (lyophilised) | Stable at 2–8 °C lyophilised for 12+ months. |
| Storage (reconstituted) | Reconstituted: store at 2–8 °C, use within 14 days. |
| Clinical / regulatory status | Investigational research analogue. |
IGF-1 LR3 (Long-Arg3 IGF-1) is a modified 83-amino-acid analogue of insulin-like growth factor-1 with an arginine substitution at position 3 and an N-terminal 13-amino-acid extension. Supplied as lyophilised powder for in-vitro research use only.
The above describes how this compound is characterised in the published peer-reviewed literature. It is not a claim about effects in humans.
IGF-1 LR3 is supplied as a lyophilised (freeze-dried) powder in a sealed glass vial. For laboratory reconstitution, add the desired volume of diluent (typically bacteriostatic water) slowly down the side wall of the vial. Swirl gently until fully dissolved - do not vortex or shake. Store reconstituted solutions at 2–8 °C and use within 4–6 weeks.
Use our Reconstitution Volume Calculator to compute the resulting mg/ml concentration.
| State | Temperature | Shelf life |
|---|---|---|
| Lyophilised | 2–8 °C or −20 °C | Up to 24 months |
| Reconstituted | 2–8 °C | 4–6 weeks typical |
Every batch of IGF-1 LR3 we supply is independently HPLC-verified by Janoshik Analytical. Where a Janoshik report has been issued for the current batch it is supplied with the order and carries a unique verification key that can be authenticated against Janoshik's records. Reported purity is consistently above 99%.
Researchers working with IGF-1 LR3 often work alongside the following compounds in the preclinical literature: