α-MSH analogue (13-AA)
A 13-amino-acid synthetic analogue of alpha-MSH with norleucine and D-phenylalanine substitutions for increased potency.
| Compound | MT-1 (Afamelanotide) |
| Research category | Melanocortin Research |
| Available sizes | 10mg |
| Pricing | From £25 |
| Format | Lyophilised powder in sealed vial |
| Purity | >99% by HPLC (Janoshik Analytical, batch-verified) |
| Intended use | In-vitro laboratory research only. Not for human consumption. |
Reference data drawn from public databases (PubChem, UniProt) and peer-reviewed literature. For research and laboratory characterisation only.
| Compound class | Synthetic 13-amino-acid α-MSH analogue (Afamelanotide) |
| Molecular formula | C78H111N21O19 |
| Molecular weight | 1646.85 g/mol |
| CAS Registry Number | 75921-69-6 |
| PubChem CID | 16154396 |
| Number of residues | 13 |
| Amino acid sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| Receptor / mechanism | Melanocortin-1 receptor agonist (selective). |
| Reported half-life | Reported ~30 minutes in human serum (free peptide). |
| Solubility | Lyophilised powder reconstitutes in bacteriostatic water for laboratory use. |
| Storage (lyophilised) | Stable at 2–8 °C lyophilised for 24+ months. |
| Storage (reconstituted) | Reconstituted: store at 2–8 °C, use within 14 days. |
| Clinical / regulatory status | Approved (Scenesse) for erythropoietic protoporphyria research applications. |
Melanotan-1 (Afamelanotide) is a synthetic 13-amino-acid analogue of α-melanocyte-stimulating hormone (α-MSH). Characterised in the literature as a melanocortin-1 receptor (MC1R) agonist. Supplied as lyophilised powder for in-vitro research use only.
The above describes how this compound is characterised in the published peer-reviewed literature. It is not a claim about effects in humans.
MT-1 (Afamelanotide) is supplied as a lyophilised (freeze-dried) powder in a sealed glass vial. For laboratory reconstitution, add the desired volume of diluent (typically bacteriostatic water) slowly down the side wall of the vial. Swirl gently until fully dissolved - do not vortex or shake. Store reconstituted solutions at 2–8 °C and use within 4–6 weeks.
Use our Reconstitution Volume Calculator to compute the resulting mg/ml concentration.
| State | Temperature | Shelf life |
|---|---|---|
| Lyophilised | 2–8 °C or −20 °C | Up to 24 months |
| Reconstituted | 2–8 °C | 4–6 weeks typical |
Every batch of MT-1 (Afamelanotide) we supply is independently HPLC-verified by Janoshik Analytical. Where a Janoshik report has been issued for the current batch it is supplied with the order and carries a unique verification key that can be authenticated against Janoshik's records. Reported purity is consistently above 99%.
Researchers working with MT-1 (Afamelanotide) often work alongside the following compounds in the preclinical literature: